Living to a ripe old age

Before you read any further, I should point out this is not strictly stroke related, but it is about getting old and may of general interest.

If you want only stroke specific information, this article is not for you - sorry!

I came across an article which I found interesting and would like to share the “Key Takeaways” from it.

It was an article on ageing.

If you wish to read it, please continue, otherwise sorry to have wasted your time …

Research on oldest possible age humans could live

Key Takeaways

  • Scientists estimate the maximum human lifespan could reach around 190 years if all ageing mechanisms except somatic mutations were eliminated or treated.

  • The research comes from the Skolkovo Institute of Science and Technology (Russia), where scientists modelled ageing driven solely by somatic mutations—tiny DNA errors that occur when cells divide.

  • Somatic mutations accumulate over time, gradually impairing cell function. Even if all other ageing processes were solved, these mutations would still eventually lead to organ failure and death.

  • Their model suggests that, under ideal conditions, humans could theoretically live 146–194 years, depending on assumptions used.

  • Different organs age differently:

    • Skin and liver cells regenerate well and could last longer.

    • Heart and brain cells are mostly irreplaceable, so mutations accumulate steadily.

  • The findings highlight that somatic mutations are a weak ageing driver alone, but become critical when combined with other ageing mechanisms.

  • The article also mentions current anti‑ageing efforts, including:

    • Biohacker Bryan Johnson, who spends millions attempting to reduce his biological age.

    • Life Biosciences, which received FDA approval for a human trial aiming to reverse optic nerve damage—seen as a test case for rejuvenation therapies.

Link to original article - which may not be avaialble depending on when you are reading this.

Oldest possible age humans could live - a research article

:pray:

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190 wow. I wonder what life would be like if we lived that long.

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I always thought I’d be part of the twenty-seven club, but it seems I was not destined to be let in. :laughing:

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@ManjiB

I don’t know about ripen but I’ve gone soft and squidgy around the middle.

Does that count?

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Yes, I guess destiny may have something to do with it.

For those interested in the 2-7 clup.

You have been warned!

Some blurb about the 2-7 clup

Approximately 0.1% to 0.25% of the population dies between their 27th and 28th birthdays in developed countries like the United States and the United Kingdom.

Out of 100,000 people reaching the age of 27, between 100 and 250 individuals will pass away at that ages. Demographically, age 27 is near the absolute lifetime low point for human mortality risk.

Key Mortality Figures for Age 27

Below info c/o U.S. Social Security Administration (SSA) Actuarial Life Tables and the UK Office for National Statistics (ONS):

  • Annual Probability of Dying: At the age of 27, your statistical probability of dying before turning 28 is roughly 0.11% for females and 0.25% for males.

  • Share of Total Annual Deaths: In any given year across the entire population, deaths at age 27 account for less than 0.05% of total deaths. The vast majority of deaths are concentrated among those aged 75 to 90.


Primary Causes of Death at 27
The human body is generally at peak physical resilience in its late twenties, chronic illnesses such as heart disease and cancer are highly uncommon at this age. Instead, the leading causes of death for 27-year-olds are overwhelmingly tied to external factors:

  • Unintentional Injuries: Motor vehicle accidents and accidental drug overdoses / poisonings.

  • Suicide: Self-harm stands as one of the highest drivers of mortality for individuals aged 20 to 34.

  • Homicide: Violent external causes

And now for why we are discussing this …

The “27 Club” Myth vs. Reality

  • This question is frequently prompted by the cultural concept of the “27 Club” — the famous phenomenon involving iconic musicians like Jimi Hendrix, Janis Joplin, Jim Morrison, Amy Winehouse, and Kurt Cobain who died at this exact age.

  • Extensive statistical analyses conducted by epidemiologists and data scientists have repeatedly proven that there is no statistical spike in deaths at age 27 for musicians or the general public. A person is no more likely to die at 27 than they are at 26 or 28; the perceived phenomenon is purely the result of confirmation bias.

Question for you Rupert. How old were you when you first thought you’d be a part of the 27 club and was there a reason for thinking this way?

Supplemental: And when you realised you were not going to be a part of the 27 club, how did you feel or what did you think then?

Yes, Bobbi. Being soft and squidgy around the middle absolutely counts :slight_smile:

:pray:

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Nothing more than yooffool histrionics I suspect, when I would surpass an estimated age for my predicted demise, I’d come up with another one and then another one, and another one. If, by chance, I make it to one hundred, I’d have to make up a one hundred and five club. I think, when younger, in my late teens and early twenties, I could never imagine what I would be like in the twilight years, there were no aging AI image apps back then. I just couldn’t see myself as an old man, and now that I am a middle aged old man, I can’t see myself as an older man. My reminiscence bump is stuck in my teen years, and that seems to reflect my age identity.